Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
YLR462WPutative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII; Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily. (202 aa)    
Predicted Functional Partners:
YAR060C
Putative uncharacterized protein YAR060C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YAR060C has a paralog, YHR212C, that arose from a segmental duplication.
   
  
 0.764
YAR053W
Putative uncharacterized protein YA5053W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.
   
  
 0.741
YHR212W-A
Uncharacterized protein YAR061W; Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YHR212W-A has a paralog, YAR061W, that arose from a segmental duplication.
   
  
 0.693
YAL064W-B
Uncharacterized membrane protein YAL064W-B; Fungal-specific protein of unknown function.
   
  
 0.690
YPL067C
Uncharacterized protein YPL067C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene.
   
  
 0.677
YHL044W
DUP240 protein YHL044W; Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern.
   
  
 0.662
YFL068W
UPF0479 membrane protein YFL068W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol.
   
  
 0.661
YPR195C
Uncharacterized protein YPR195C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.
      
 0.639
YNR064C
Uncharacterized hydrolase YNR064C; Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides; Belongs to the DmpD/TodF/XylF esterase family.
      
 0.626
YML133C
Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron.
   
   
0.618
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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