| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIM32 | DAL1 | YML050W | YIR027C | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | 0.596 |
| AIM32 | MRX11 | YML050W | YPL041C | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | MIOREX complex component 11; Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length. | 0.636 |
| AIM32 | OSM1 | YML050W | YJR051W | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.706 |
| AIM32 | SOD2 | YML050W | YHR008C | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix. | 0.818 |
| AIM32 | URA1 | YML050W | YKL216W | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid. | 0.783 |
| AIM32 | URA10 | YML050W | YMR271C | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. | 0.619 |
| AIM32 | URA3 | YML050W | YEL021W | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound. | 0.619 |
| AIM32 | URA5 | YML050W | YML106W | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. | 0.619 |
| AIM32 | YIL152W | YML050W | YIL152W | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Uncharacterized protein YIL152W; Putative protein of unknown function. | 0.652 |
| AIM32 | YJL213W | YML050W | YJL213W | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | Uncharacterized protein YJL213W; Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p; Belongs to the metallo-dependent hydrolases superfamily. | 0.596 |
| DAL1 | AIM32 | YIR027C | YML050W | Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | 0.596 |
| DAL1 | URA1 | YIR027C | YKL216W | Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid. | 0.840 |
| DAL1 | URA10 | YIR027C | YMR271C | Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. | 0.564 |
| DAL1 | URA3 | YIR027C | YEL021W | Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound. | 0.564 |
| DAL1 | URA5 | YIR027C | YML106W | Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. | Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. | 0.564 |
| MRX11 | AIM32 | YPL041C | YML050W | MIOREX complex component 11; Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length. | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | 0.636 |
| OSM1 | AIM32 | YJR051W | YML050W | Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | 0.706 |
| SOD2 | AIM32 | YHR008C | YML050W | Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix. | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | 0.818 |
| SOD2 | URA3 | YHR008C | YEL021W | Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix. | Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound. | 0.408 |
| URA1 | AIM32 | YKL216W | YML050W | Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid. | Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss. | 0.783 |
