node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERV14 | ERV15 | YGL054C | YBR210W | ER-derived vesicles protein ERV14; COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication. | ER-derived vesicles protein ERV15; Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication. | 0.519 |
ERV14 | SMA2 | YGL054C | YML066C | ER-derived vesicles protein ERV14; COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication. | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | 0.678 |
ERV15 | ERV14 | YBR210W | YGL054C | ER-derived vesicles protein ERV15; Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication. | ER-derived vesicles protein ERV14; COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication. | 0.519 |
ERV15 | SMA2 | YBR210W | YML066C | ER-derived vesicles protein ERV15; Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication. | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | 0.756 |
LPL1 | SMA2 | YOR059C | YML066C | Lipid droplet phospholipase 1; Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress. | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | 0.414 |
LPL1 | YIL165C | YOR059C | YIL165C | Lipid droplet phospholipase 1; Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress. | Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene; Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family. | 0.495 |
LPL1 | YOR376W-A | YOR059C | YOR376W-A | Lipid droplet phospholipase 1; Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress. | Uncharacterized protein YOR376W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. | 0.792 |
PRM1 | SMA2 | YNL279W | YML066C | Plasma membrane fusion protein PRM1; Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p. | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | 0.601 |
RRT12 | SMA2 | YCR045C | YML066C | Subtilase-type proteinase RRT12; Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores. | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | 0.726 |
RRT12 | SPO77 | YCR045C | YLR341W | Subtilase-type proteinase RRT12; Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores. | Sporulation-specific protein 77; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; required with Sps1p for phosphorylation and turnover of Ssp1p; dispensable for both nuclear divisions during meiosis. | 0.554 |
SMA2 | ERV14 | YML066C | YGL054C | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | ER-derived vesicles protein ERV14; COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication. | 0.678 |
SMA2 | ERV15 | YML066C | YBR210W | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | ER-derived vesicles protein ERV15; Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication. | 0.756 |
SMA2 | LPL1 | YML066C | YOR059C | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | Lipid droplet phospholipase 1; Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress. | 0.414 |
SMA2 | PRM1 | YML066C | YNL279W | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | Plasma membrane fusion protein PRM1; Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p. | 0.601 |
SMA2 | RRT12 | YML066C | YCR045C | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | Subtilase-type proteinase RRT12; Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores. | 0.726 |
SMA2 | SPO77 | YML066C | YLR341W | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | Sporulation-specific protein 77; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; required with Sps1p for phosphorylation and turnover of Ssp1p; dispensable for both nuclear divisions during meiosis. | 0.878 |
SMA2 | SSO1 | YML066C | YPL232W | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | Protein SSO1; Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication. | 0.447 |
SMA2 | YDL129W | YML066C | YDL129W | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | Uncharacterized protein YDL129W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress. | 0.510 |
SMA2 | YIL165C | YML066C | YIL165C | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene; Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family. | 0.416 |
SMA2 | YOR376W-A | YML066C | YOR376W-A | Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family. | Uncharacterized protein YOR376W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. | 0.700 |