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ATR1 protein (Saccharomyces cerevisiae) - STRING interaction network
"ATR1" - Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide in Saccharomyces cerevisiae
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Known Interactions
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Predicted Interactions
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textmining
co-expression
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ATR1Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; Putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. Probable ATP-dependent export permease. Appears to confer resistance only to aminotriazole (542 aa)    
Predicted Functional Partners:
FLR1
Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; Probable efflux transporter. Confers resistance to the azole derivative fluconazole (FCZ) (548 aa)
   
   
  0.791
SGE1
Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations; Drug export permease. Multi-copy suppressor of loss-of- function mutation of GAL11. Involved specifically in transcription of GAL4-dependent genes. Can link GAL4 with the basal transcription machinery if GAL11 is missing. Confers resistance to 10-N-nonyl acridine orange (NAO) and in general to cationic dyes (543 aa)
   
     
  0.717
GCN4
bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence- 5’-TGA[CG]TCA- 3’ (281 aa)
       
 
  0.699
AZR1
Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole; Transporter protein required for adaptation to high stress imposed by low-chain organic acids, in particular by acetic acid, and for resistance to azoles, especially to ketoconazole and fluconazole (613 aa)
   
     
  0.681
VBA2
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine (474 aa)
   
     
  0.680
VBA3
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of histidine and lysine (458 aa)
   
     
  0.662
VBA5
Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny; Transporter required for vacuolar uptake of basic amino acids (582 aa)
   
     
  0.662
SNQ2
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species; Could be an ATP-dependent permease. Confers hyper- resistance to the mutagens 4-nitroquinoline-N-oxide (4-NQO) and triaziquone, as well as to the chemicals sulphomethuron methyl phenanthroline when present in multiple copies. Exhibits nucleoside triphosphatase activity (1501 aa)
     
 
  0.646
TPO1
Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane; Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Catalyzes polyamine uptake at alkaline pH and excretion at acidic pH. Recognizes spermidine, spermine and putrescine, the polyamine analogs methylglyoxal bis(guanylhydrazone) (MGBG) and paraquat, the antimalarial drug quinidine, and cycloheximide. Confers res [...] (586 aa)
         
  0.626
QDR1
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban; Multidrug resistance transporter involved in resistance and adaptation to quinidine and ketoconazole (563 aa)
         
  0.625
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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