node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCR4 | NGL1 | YAL021C | YOL042W | Glucose-repressible alcohol dehydrogenase transcriptional effector; Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; Belongs to the CCR4/nocturin family. | RNA exonuclease NGL1; Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the CCR4/nocturin family. | 0.682 |
CCR4 | NGL3 | YAL021C | YML118W | Glucose-repressible alcohol dehydrogenase transcriptional effector; Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; Belongs to the CCR4/nocturin family. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.551 |
CCR4 | PAN2 | YAL021C | YGL094C | Glucose-repressible alcohol dehydrogenase transcriptional effector; Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; Belongs to the CCR4/nocturin family. | Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; Belongs to the peptidase C19 family. PAN2 subfamily. | 0.985 |
ECM12 | FYV7 | YHR021W-A | YLR068W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | 0.602 |
ECM12 | LCP5 | YHR021W-A | YER127W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | 0.596 |
ECM12 | MCH2 | YHR021W-A | YKL221W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Probable transporter MCH2; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.538 |
ECM12 | MFM1 | YHR021W-A | YPL060W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. | 0.690 |
ECM12 | NGL3 | YHR021W-A | YML118W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.760 |
ECM12 | PIG2 | YHR021W-A | YIL045W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | GSY2-interacting protein PIG2; Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication. | 0.552 |
FYV7 | ECM12 | YLR068W | YHR021W-A | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.602 |
FYV7 | LCP5 | YLR068W | YER127W | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | 0.713 |
FYV7 | NGL3 | YLR068W | YML118W | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.465 |
LCP5 | ECM12 | YER127W | YHR021W-A | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.596 |
LCP5 | FYV7 | YER127W | YLR068W | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | 0.713 |
LCP5 | NGL3 | YER127W | YML118W | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.441 |
MCH2 | ECM12 | YKL221W | YHR021W-A | Probable transporter MCH2; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.538 |
MCH2 | NGL3 | YKL221W | YML118W | Probable transporter MCH2; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.408 |
MFM1 | ECM12 | YPL060W | YHR021W-A | Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.690 |
MFM1 | NGL3 | YPL060W | YML118W | Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.524 |
NGL1 | CCR4 | YOL042W | YAL021C | RNA exonuclease NGL1; Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the CCR4/nocturin family. | Glucose-repressible alcohol dehydrogenase transcriptional effector; Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; Belongs to the CCR4/nocturin family. | 0.682 |