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MAC1 protein (Saccharomyces cerevisiae) - STRING interaction network
"MAC1" - Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport in Saccharomyces cerevisiae
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MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport; Regulatory protein involved in Cu/Fe utilization and stress resistance. Involved in basal level transcription of FRE1 and H(2)O(2)-induced transcription of CTT1. Regulates the transcription of CTR1 and CTR3 via the copper ion responsive elements in their promoters. Required for degradation of CTR1 (417 aa)    
Predicted Functional Partners:
FRE1
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels; Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake (686 aa)
       
 
  0.889
CTR2
Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm (189 aa)
       
 
  0.857
AFT1
Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability; Probable transcription factor that activates the genes for FRE1, FRE2 and FET3 in response to iron deprivation. Iron could interact directly with AFT1 and inhibits its activity (690 aa)
     
 
  0.834
IRC7
Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner (340 aa)
     
   
  0.833
REE1
Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle; Functions in the galactose metabolic pathway via the GAL83 protein and that it may control the level of ENO1 (198 aa)
           
  0.829
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide (562 aa)
           
  0.829
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae; Required for high affinity copper (probably reduced Cu I) transport into the cell (241 aa)
           
  0.748
FET3
Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; Iron transport multicopper ferroxidase required for Fe(2+) ion high affinity uptake. Required to oxidize Fe(2+) and release it from the transporter. Essential component of copper- dependent iron transport (636 aa)
           
  0.737
FTR1
High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; Permease for high affinity iron uptake (404 aa)
           
  0.726
FRE2
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels; Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and [...] (711 aa)
           
  0.697
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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