node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARA1 | ARA2 | YBR149W | YMR041C | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product. | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | 0.892 |
ARA1 | BDH2 | YBR149W | YAL061W | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product. | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.614 |
ARA1 | GCY1 | YBR149W | YOR120W | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product. | Glycerol 2-dehydrogenase (NADP(+)); Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication. | 0.438 |
ARA1 | GRE3 | YBR149W | YHR104W | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product. | Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress. | 0.715 |
ARA1 | YDL124W | YBR149W | YDL124W | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product. | NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress. | 0.500 |
ARA1 | YJR096W | YBR149W | YJR096W | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product. | Uncharacterized oxidoreductase YJR096W; Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS. | 0.483 |
ARA2 | ARA1 | YMR041C | YBR149W | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product. | 0.892 |
ARA2 | BDH2 | YMR041C | YAL061W | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.558 |
ARA2 | CYB2 | YMR041C | YML054C | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | 0.676 |
ARA2 | ECL1 | YMR041C | YGR146C | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation. | 0.515 |
ARA2 | GCY1 | YMR041C | YOR120W | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Glycerol 2-dehydrogenase (NADP(+)); Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication. | 0.504 |
ARA2 | GRE3 | YMR041C | YHR104W | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress. | 0.504 |
ARA2 | SPE3 | YMR041C | YPR069C | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells. | 0.535 |
ARA2 | SPG5 | YMR041C | YMR191W | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Stationary phase protein 5; Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources. | 0.508 |
ARA2 | YDL124W | YMR041C | YDL124W | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress. | 0.498 |
ARA2 | YJR096W | YMR041C | YJR096W | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | Uncharacterized oxidoreductase YJR096W; Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS. | 0.693 |
BDH2 | ARA1 | YAL061W | YBR149W | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product. | 0.614 |
BDH2 | ARA2 | YAL061W | YMR041C | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. | 0.558 |
BDH2 | CYB2 | YAL061W | YML054C | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions. | 0.608 |
BDH2 | GCY1 | YAL061W | YOR120W | Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family. | Glycerol 2-dehydrogenase (NADP(+)); Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication. | 0.433 |