node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AVO1 | AVO2 | YOL078W | YMR068W | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | 0.999 |
AVO1 | BIT2 | YOL078W | YBR270C | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication | 0.980 |
AVO1 | BIT61 | YOL078W | YJL058C | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication | 0.997 |
AVO1 | KOG1 | YOL078W | YHR186C | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; Belongs to the WD repeat RAPTOR family | 0.997 |
AVO1 | LST8 | YOL078W | YNL006W | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Target of rapamycin complex subunit LST8; Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat | 0.999 |
AVO1 | SLM1 | YOL078W | YIL105C | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1; Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication | 0.956 |
AVO1 | TCO89 | YOL078W | YPL180W | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin | 0.933 |
AVO1 | TOR1 | YOL078W | YJR066W | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Serine/threonine-protein kinase TOR1; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication | 0.999 |
AVO1 | TOR2 | YOL078W | YKL203C | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Serine/threonine-protein kinase TOR2; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication; Belongs to the PI3/PI4-kinase family | 0.999 |
AVO1 | TSC11 | YOL078W | YER093C | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p); TORC2 is a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain; Belongs to the RICTOR family | 0.999 |
AVO2 | AVO1 | YMR068W | YOL078W | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family | 0.999 |
AVO2 | BIT2 | YMR068W | YBR270C | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication | 0.956 |
AVO2 | BIT61 | YMR068W | YJL058C | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication | 0.992 |
AVO2 | KOG1 | YMR068W | YHR186C | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; Belongs to the WD repeat RAPTOR family | 0.961 |
AVO2 | LST8 | YMR068W | YNL006W | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Target of rapamycin complex subunit LST8; Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat | 0.997 |
AVO2 | SLM1 | YMR068W | YIL105C | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1; Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication | 0.990 |
AVO2 | TCO89 | YMR068W | YPL180W | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin | 0.931 |
AVO2 | TOR1 | YMR068W | YJR066W | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Serine/threonine-protein kinase TOR1; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication | 0.962 |
AVO2 | TOR2 | YMR068W | YKL203C | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Serine/threonine-protein kinase TOR2; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication; Belongs to the PI3/PI4-kinase family | 0.999 |
AVO2 | TSC11 | YMR068W | YER093C | Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth | Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p); TORC2 is a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain; Belongs to the RICTOR family | 0.999 |