STRINGSTRING
IRC21 protein (Saccharomyces cerevisiae) - STRING interaction network
"IRC21" - Protein of unknown function in Saccharomyces cerevisiae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
IRC21Protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study; Involved in resistance to carboplatin and cisplatin. Is probably involved in a pathway contributing to genomic integrity (201 aa)    
Predicted Functional Partners:
PHA2
Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway (334 aa)
       
      0.748
RAD17
Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. Associates with sites of DNA damage and modulates the MEC1 signaling pathway and the activation of RAD53 in response to DNA [...] (401 aa)
       
 
  0.679
YLR407W
Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus; Deletion results in antifungal drug fluconazole- resistant phenotype (228 aa)
           
  0.620
YOR364W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C (122 aa)
           
  0.580
YDL071C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W (124 aa)
           
  0.520
YML122C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data (126 aa)
           
  0.519
IRC24
Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci; Reduces benzil stereospecifically to (S)-benzoin. Is probably involved in a pathway contributing to genomic integrity (263 aa)
           
  0.517
XRS2
Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling; During meiosis is involved in homologous recombination and during vegetative growth it is necessary for DNA repair. It probably regulates the 5’-3’ exonuclease degradation of double strand breaks either at the initiation stage or a later stage (854 aa)
           
  0.516
HRQ1
Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS); Helicase with 3’-5’ helicase activity involved in genome stability (PubMed-23456718, PubMed-24440721, PubMed-24700328). Functions in the RAD4-dependent nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair (PubMed-24440721, PubMed-24682993). Unwinds relatively long duplex DNA up to 120-bp and requires a long 3’-tail of at least 70 nu [...] (1077 aa)
           
  0.509
IRC6
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; Involved in gross chromosomal rearrangements (GCRs) and telomere healing (237 aa)
           
  0.508
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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