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ISF1 protein (Saccharomyces cerevisiae) - STRING interaction network
"ISF1" - Serine-rich, hydrophilic protein with similarity to Mbr1p in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ISF1Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; Could influence the NAM7/UPF1 function, possibly at the level of mRNA turnover. Participates in mitochondrial biogenesis (338 aa)    
Predicted Functional Partners:
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; Regulates the activity of glycogen synthase. It is most probably a regulatory subunit for protein phosphatase type 1 (793 aa)
     
   
  0.939
RGI1
Protein of unknown function involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions (161 aa)
     
   
  0.875
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation (501 aa)
     
   
  0.842
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; Participates in mitochondrial biogenesis and stress response (339 aa)
     
   
  0.838
YMR206W
Putative protein of unknown function; YMR206W is not an essential gene (313 aa)
     
   
  0.839
TMA10
Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p (86 aa)
     
   
  0.810
YNL144C
Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study (740 aa)
     
        0.806
IGD1
Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; Acts as an inhibitor of GDB1, enhancing the ability of cells to store glucose as glycogen (195 aa)
     
   
  0.704
HAP2
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5’-CCAAT-3’. HAP2 has primarily a structural role in the HAP complexes I and II (265 aa)
       
 
  0.627
MPC3
Putative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Mediates the uptake of pyruvate into mitochondria (146 aa)
     
   
  0.569
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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