node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMR2 | GCG1 | YOR093C | YER163C | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle. | 0.693 |
CMR2 | TDA3 | YOR093C | YHR009C | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1. | 0.728 |
CMR2 | YER152C | YOR093C | YER152C | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | Uncharacterized protein YER152C; Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene. | 0.712 |
CMR2 | YGR111W | YOR093C | YGR111W | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | Uncharacterized protein YGR111W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus. | 0.780 |
CMR2 | YGR127W | YOR093C | YGR127W | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | Uncharacterized protein YGR127W; Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response. | 0.795 |
CMR2 | YMR085W | YOR093C | YMR085W | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1. | 0.764 |
CMR2 | YOR012W | YOR093C | YOR012W | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | Uncharacterized protein YOR012W; Putative protein of unknown function. | 0.635 |
GCG1 | CMR2 | YER163C | YOR093C | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle. | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | 0.693 |
GCG1 | TDA3 | YER163C | YHR009C | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle. | Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1. | 0.559 |
GCG1 | YER152C | YER163C | YER152C | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle. | Uncharacterized protein YER152C; Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene. | 0.647 |
GCG1 | YGR111W | YER163C | YGR111W | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle. | Uncharacterized protein YGR111W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus. | 0.635 |
GCG1 | YGR127W | YER163C | YGR127W | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle. | Uncharacterized protein YGR127W; Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response. | 0.759 |
GCG1 | YMR085W | YER163C | YMR085W | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle. | Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1. | 0.700 |
GCG1 | YOR012W | YER163C | YOR012W | Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle. | Uncharacterized protein YOR012W; Putative protein of unknown function. | 0.606 |
GFA1 | RIB4 | YKL104C | YOL143C | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication. | Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase. | 0.872 |
GFA1 | YMR084W | YKL104C | YMR084W | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication. | Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1. | 0.903 |
GFA1 | YMR085W | YKL104C | YMR085W | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication. | Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1. | 0.804 |
RIB4 | GFA1 | YOL143C | YKL104C | Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase. | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication. | 0.872 |
RIB4 | YMR084W | YOL143C | YMR084W | Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase. | Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1. | 0.858 |
RIB4 | YMR085W | YOL143C | YMR085W | Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase. | Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1. | 0.879 |