STRINGSTRING
ICY1 protein (Saccharomyces cerevisiae) - STRING interaction network
"ICY1" - Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA in Saccharomyces cerevisiae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
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Experiments
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[Homology]
Score
ICY1Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; Required for viability of cells lacking mtDNA (127 aa)    
Predicted Functional Partners:
TIM18
Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as external driving force. Its role in the complex is unclear but it may be involved in the assembly and stabilization of the TIM22 complex (192 aa)
       
 
  0.667
YPL222C-A
Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching (81 aa)
           
  0.638
BOR1
Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1; Functions in boric acid/borate export across the plasma membrane, and thereby protects yeast cells from boron toxicity. Involved in the trafficking of proteins to the vacuole (576 aa)
           
  0.519
YMR194C-A
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (74 aa)
     
   
  0.511
SLP1
Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; May be involved in membrane protein folding (PubMed-19325107). Required for localization of MPS3 to the nuclear envelope (PubMed-23275891) (587 aa)
           
  0.469
RPI1
Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation; Negative regulator of the Ras-cyclic AMP pathway. Negatively regulate the activity of normal but not mutationally activated Ras proteins. The down-regulatory effect of RPI1 requires the presence of one of the two Ras GTPase activators, IRA1 and IRA2 (407 aa)
     
   
  0.464
YOR343C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (108 aa)
           
  0.449
YDR133C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C (111 aa)
     
   
  0.431
YGR050C
Protein of unknown function; mRNA identified as translated by ribosome profiling data (118 aa)
           
  0.418
AIM34
Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss (198 aa)
           
  0.410
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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