STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ICY1Interacting with cytoskeleton protein 1; Protein of unknown function; required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; ICY1 has a paralog, ICY2, that arose from the whole genome duplication. (127 aa)    
Predicted Functional Partners:
YGR050C
Uncharacterized protein YGR050C; Protein of unknown function; mRNA identified as translated by ribosome profiling data.
   
  
 0.805
YLR297W
Uncharacterized vacuolar protein YLR297W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication.
   
  
 0.708
AEP2
ATPase expression protein 2, mitochondrial; Mitochondrial protein; likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader; Belongs to the AEP2 family.
      
 0.638
YMR194C-A
Putative uncharacterized protein YMR194C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.
   
  
 0.620
RIT1
tRNA A64-2'-O-ribosylphosphate transferase; Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA.
      
 0.614
RSN1
Uncharacterized protein RSN1; Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane; Belongs to the CSC1 (TC 1.A.17) family.
      
 0.582
AFI1
ARF3-interacting protein 1; Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p.
      
 0.560
YMR245W
Putative uncharacterized protein YMR245W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.
   
  
 0.558
YMR265C
Uncharacterized protein YMR265C; Putative protein of unknown function.
      
 0.551
AIM41
Altered inheritance of mitochondria protein 41, mitochondrial; Protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss.
   
  
 0.546
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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