| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENP1 | MTF1 | YBR247C | YMR228W | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family. | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | 0.818 |
| ENP1 | RPO41 | YBR247C | YFL036W | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family. | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Rpo41p also synthesizes RNA primers for mitochondrial DNA replication. | 0.433 |
| MRP17 | MRPS16 | YKL003C | YPL013C | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRP17 | MRPS9 | YKL003C | YBR146W | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRP17 | MTF1 | YKL003C | YMR228W | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | 0.936 |
| MRP17 | MTF2 | YKL003C | YDL044C | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial transcription factor 2; Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription. | 0.435 |
| MRP17 | RSM10 | YKL003C | YDR041W | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins. | 0.999 |
| MRP17 | RSM22 | YKL003C | YKL155C | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase. | 0.997 |
| MRP17 | RSM24 | YKL003C | YDR175C | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRPS16 | MRP17 | YPL013C | YKL003C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | 0.999 |
| MRPS16 | MRPS9 | YPL013C | YBR146W | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRPS16 | MTF1 | YPL013C | YMR228W | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | 0.923 |
| MRPS16 | MTF2 | YPL013C | YDL044C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial transcription factor 2; Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription. | 0.496 |
| MRPS16 | RSM10 | YPL013C | YDR041W | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins. | 0.999 |
| MRPS16 | RSM22 | YPL013C | YKL155C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase. | 0.998 |
| MRPS16 | RSM24 | YPL013C | YDR175C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRPS9 | MRP17 | YBR146W | YKL003C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | 0.999 |
| MRPS9 | MRPS16 | YBR146W | YPL013C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRPS9 | MTF1 | YBR146W | YMR228W | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | 0.934 |
| MRPS9 | MTF2 | YBR146W | YDL044C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial transcription factor 2; Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription. | 0.434 |