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RRP5 protein (Saccharomyces cerevisiae) - STRING interaction network
"RRP5" - RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs in Saccharomyces cerevisiae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RRP5RNA binding protein with preference for single stranded tracts of U’s involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA (1729 aa)    
Predicted Functional Partners:
ECM16
Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis; Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis. May play a role in restructuring of the pre-rRNA (1267 aa)
     
  0.999
NOP58
Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; Required for pre-18S rRNA processing. May bind microtubules (511 aa)
     
  0.999
NOP14
Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (810 aa)
     
  0.999
UTP20
Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (2493 aa)
     
  0.999
PWP2
Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis; Required for bud-site selection and cell separation. Also involved in nucleolar processing of pre-18S ribosomal RNA (923 aa)
     
  0.999
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (1237 aa)
     
  0.999
NAN1
U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (896 aa)
     
  0.999
MPP10
Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (593 aa)
     
  0.999
MAK21
Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein; Required for 60S ribosomal subunit synthesis (1025 aa)
     
 
  0.999
NOP56
Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2’-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects; Required for 60S ribosomal subunit synthesis (504 aa)
     
  0.999
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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