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ZRC1 protein (Saccharomyces cerevisiae) - STRING interaction network
"ZRC1" - Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage in Saccharomyces cerevisiae
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ZRC1Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm; Probably responsible for the uptake of zinc and cadmium ions (442 aa)    
Predicted Functional Partners:
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor; High-affinity zinc transport protein (376 aa)
     
   
  0.927
ZRT3
Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency; Transports zinc from storage in the vacuole to the cytoplasm (503 aa)
   
   
  0.914
ZRT2
Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor; Low-affinity zinc transport protein. Active in zinc- replete cells and is time-, temperature- and concentration- dependent and prefers zinc over other metals as its substrate (422 aa)
     
   
  0.874
ZRG17
Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc (605 aa)
     
 
  0.858
YKE4
Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family; Zinc transporter whose role depends on the zinc status of the cells. It helps to balance zinc levels between the cytosol and the secretory pathway. It transports zinc into the secretory pathway in a zinc-adequate environment and in a high zinc medium. In high zinc medium, transport of zinc into the secretory pathway is a way to eliminate zinc from the cytosol. Under low cytosolic zinc [...] (346 aa)
     
 
  0.852
YMR209C
Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene (457 aa)
       
      0.800
ZAP1
Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains; Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation (880 aa)
           
  0.795
FET4
Low-affinity Fe(II) transporter of the plasma membrane; Required for Fe(2+) ion low affinity uptake (552 aa)
           
  0.700
SDD3
Putative metalloprotease (1037 aa)
     
      0.687
RCK2
Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; Serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment (610 aa)
     
 
  0.608
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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