node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FCP1 | RPB2 | YMR277W | YOR151C | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | 0.976 |
FCP1 | RPB3 | YMR277W | YIL021W | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | 0.987 |
FCP1 | RPB4 | YMR277W | YJL140W | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.963 |
FCP1 | RPB7 | YMR277W | YDR404C | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.991 |
FCP1 | RPO21 | YMR277W | YDL140C | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. | 0.999 |
FCP1 | SPT5 | YMR277W | YML010W | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life. | 0.967 |
FCP1 | SSU72 | YMR277W | YNL222W | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo. | 0.977 |
FCP1 | SUA7 | YMR277W | YPR086W | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | 0.980 |
FCP1 | TFG1 | YMR277W | YGR186W | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.999 |
FCP1 | TFG2 | YMR277W | YGR005C | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. | 0.963 |
RPB2 | FCP1 | YOR151C | YMR277W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia. | 0.976 |
RPB2 | RPB3 | YOR151C | YIL021W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | 0.999 |
RPB2 | RPB4 | YOR151C | YJL140W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
RPB2 | RPB7 | YOR151C | YDR404C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
RPB2 | RPO21 | YOR151C | YDL140C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. | 0.999 |
RPB2 | SPT5 | YOR151C | YML010W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life. | 0.999 |
RPB2 | SSU72 | YOR151C | YNL222W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo. | 0.946 |
RPB2 | SUA7 | YOR151C | YPR086W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II. | 0.999 |
RPB2 | TFG1 | YOR151C | YGR186W | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74. | 0.999 |
RPB2 | TFG2 | YOR151C | YGR005C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30. | 0.999 |