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PET494 protein (Saccharomyces cerevisiae) - STRING interaction network
"PET494" - Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
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protein homology
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PET494Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane; Required for the expression of the mitochondrial gene for cytochrome c oxidase subunit III (COX3) (489 aa)    
Predicted Functional Partners:
PET54
Mitochondrial inner membrane protein; binds to the 5’ UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; Activator of specific mitochondrial mRNAs. PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3 (293 aa)
       
 
  0.974
PET111
Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane; Required for translation of the mitochondrial gene for cytochrome c oxidase subunit II (COX2) (800 aa)
       
 
  0.971
PET122
Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane; Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA (254 aa)
           
  0.955
COX3
Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Subunits I, II and III form the functional core of the enzyme complex (269 aa)
       
 
  0.937
COB
Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c (385 aa)
           
  0.860
CBS2
Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5’-untranslated leader; Translational activator of cytochrome b. The cytochrome b (coB) leader RNA may represent the target sequence for CBS1 and/ or CBS2 (389 aa)
           
  0.847
MRP17
Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator (131 aa)
           
  0.746
PET127
Protein with a role in 5’-end processing of mitochondrial RNAs, located in the mitochondrial membrane; Could be a component of the mitochondrial translation system with a role in promoting accuracy of translational initiation (800 aa)
           
  0.745
COA3
Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly; Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1 (85 aa)
           
  0.726
PET309
Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs); Required for initiation of translation of the COX1 coding region. Also involved in the stability of the intron containing transcript of COX1 (965 aa)
           
  0.699
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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