node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APC1 | YNR062C | YNL172W | YNR062C | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; Belongs to the APC1 family. | Putative membrane protein of unknown function. | 0.701 |
APC1 | YNR063W | YNL172W | YNR063W | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; Belongs to the APC1 family. | Uncharacterized transcriptional regulatory protein YNR063W; Putative zinc-cluster protein of unknown function. | 0.456 |
BUR6 | MNT4 | YER159C | YNR059W | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | 0.416 |
BUR6 | YNR062C | YER159C | YNR062C | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | Putative membrane protein of unknown function. | 0.631 |
CHL4 | YNR062C | YDR254W | YNR062C | Inner kinetochore subunit CHL4; Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; forms a stable complex with Iml3p; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15; Belongs to the CENP-N/CHL4 family. | Putative membrane protein of unknown function. | 0.420 |
DSF1 | YNR062C | YEL070W | YNR062C | Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication. | Putative membrane protein of unknown function. | 0.538 |
ECM22 | YNR062C | YLR228C | YNR062C | Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant activator of filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[2]-Cys[6] binuclear cluster; ECM22 has a paralog, UPC2, that arose from the whole genome duplication. | Putative membrane protein of unknown function. | 0.535 |
MNT4 | BUR6 | YNR059W | YER159C | Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1. | 0.416 |
MNT4 | YER138W-A | YNR059W | YER138W-A | Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication. | 0.832 |
MNT4 | YHR218W | YNR059W | YHR218W | Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | Helicase-like protein encoded within the telomeric Y' element. | 0.698 |
MNT4 | YNR062C | YNR059W | YNR062C | Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | Putative membrane protein of unknown function. | 0.871 |
SKY1 | YER138W-A | YMR216C | YER138W-A | Serine/threonine-protein kinase SKY1; SR protein kinase (SRPK); involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1. | Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication. | 0.510 |
SKY1 | YNR062C | YMR216C | YNR062C | Serine/threonine-protein kinase SKY1; SR protein kinase (SRPK); involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1. | Putative membrane protein of unknown function. | 0.546 |
YER138W-A | MNT4 | YER138W-A | YNR059W | Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication. | Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | 0.832 |
YER138W-A | SKY1 | YER138W-A | YMR216C | Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication. | Serine/threonine-protein kinase SKY1; SR protein kinase (SRPK); involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1. | 0.510 |
YER138W-A | YHR218W | YER138W-A | YHR218W | Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication. | Helicase-like protein encoded within the telomeric Y' element. | 0.833 |
YER138W-A | YNR062C | YER138W-A | YNR062C | Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication. | Putative membrane protein of unknown function. | 0.910 |
YHR218W | MNT4 | YHR218W | YNR059W | Helicase-like protein encoded within the telomeric Y' element. | Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively. | 0.698 |
YHR218W | YER138W-A | YHR218W | YER138W-A | Helicase-like protein encoded within the telomeric Y' element. | Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication. | 0.833 |
YHR218W | YNR062C | YHR218W | YNR062C | Helicase-like protein encoded within the telomeric Y' element. | Putative membrane protein of unknown function. | 0.839 |