node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRG1 | KDX1 | YHR209W | YKL161C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | 0.736 |
CRG1 | NCW2 | YHR209W | YLR194C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | 0.721 |
CRG1 | PRM5 | YHR209W | YIL117C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication | 0.737 |
CRG1 | SRL3 | YHR209W | YKR091W | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Protein SRL3; GTB motif (G1/S transcription factor binding) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate; SRL3 has a paralog, WHI5, that arose from the whole genome duplication | 0.930 |
CRG1 | YNR065C | YHR209W | YNR065C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Uncharacterized membrane glycoprotein YNR065C; Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene | 0.634 |
GLY1 | SGM1 | YEL046C | YJR134C | Low specificity L-threonine aldolase; Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis | Tata element modulatory factor; Protein of unknown function; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus; Belongs to the SGM1 family | 0.647 |
GLY1 | YNR065C | YEL046C | YNR065C | Low specificity L-threonine aldolase; Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis | Uncharacterized membrane glycoprotein YNR065C; Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene | 0.618 |
KDX1 | CRG1 | YKL161C | YHR209W | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | 0.736 |
KDX1 | NCW2 | YKL161C | YLR194C | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | 0.681 |
KDX1 | PRM5 | YKL161C | YIL117C | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication | 0.733 |
KDX1 | SRL3 | YKL161C | YKR091W | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Protein SRL3; GTB motif (G1/S transcription factor binding) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate; SRL3 has a paralog, WHI5, that arose from the whole genome duplication | 0.657 |
KDX1 | YNR065C | YKL161C | YNR065C | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Uncharacterized membrane glycoprotein YNR065C; Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene | 0.672 |
LSB3 | YNR065C | YFR024C-A | YNR065C | Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication | Uncharacterized membrane glycoprotein YNR065C; Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene | 0.658 |
NCW2 | CRG1 | YLR194C | YHR209W | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | 0.721 |
NCW2 | KDX1 | YLR194C | YKL161C | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | 0.681 |
NCW2 | PRM5 | YLR194C | YIL117C | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication | 0.767 |
NCW2 | SRL3 | YLR194C | YKR091W | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | Protein SRL3; GTB motif (G1/S transcription factor binding) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate; SRL3 has a paralog, WHI5, that arose from the whole genome duplication | 0.694 |
NCW2 | YNR065C | YLR194C | YNR065C | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | Uncharacterized membrane glycoprotein YNR065C; Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene | 0.676 |
PRM5 | CRG1 | YIL117C | YHR209W | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | 0.737 |
PRM5 | KDX1 | YIL117C | YKL161C | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | 0.733 |