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DSE4 protein (Saccharomyces cerevisiae) - STRING interaction network
"DSE4" - Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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DSE4Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; Involved in the dissoultion of the mother-daughter septum during cell separation (1117 aa)    
Predicted Functional Partners:
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner; Seems to be involved in the correct timing of cell separation after cytokinesis, as separation of mutant daughter cells is delayed. Could either be an enzyme necessary for glucans- degradation of the cell wall at the neck region between mother and daughter cells or a regulatory protein controlling this metabolic step (1041 aa)
     
   
  0.995
SCW11
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p; Involved in cell separation (542 aa)
     
   
  0.983
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP; Involved in pseudohyphal growth, cell wall metabolism and required for the separation of the mother and daughter cells (325 aa)
     
   
  0.953
DSE1
Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; Involved in cell wall metabolism and required for the separation of the mother and daughter cells (573 aa)
     
   
  0.940
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family; Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation (420 aa)
     
   
  0.892
CTS1
Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p; Chitinase is required for cell separation during growth of Saccharomyces cerevisiae (562 aa)
     
   
  0.841
ACE2
Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit of Ace2p during the M-to-G1 transition, causing its specific localization to daughter cell nuclei, and also increases Ace2p activity /.../phorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of the RAM network that regulates cellular polarity and morphogenesis; Plays a role in regulating basal-level expression of CUP1. Activates EGT2 transcription in the absence of SWI5 (770 aa)
     
   
  0.830
GPB2
Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p; Beta subunit of a guanine nucleotide-binding protein (G protein). G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level acco [...] (880 aa)
       
      0.800
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins (130 aa)
       
 
  0.776
CBK1
Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates /.../zation and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation (756 aa)
       
 
  0.710
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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