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IZH2 protein (Saccharomyces cerevisiae) - STRING interaction network
"IZH2" - Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis in Saccharomyces cerevisiae
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Predicted Interactions
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IZH2Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc; Probable receptor, which is involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation (317 aa)    
Predicted Functional Partners:
RAS2
GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; The S.cerevisiae Ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-AMP (322 aa)
         
  0.779
EOS1
Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene; Involved in oxidative stress resistance and N- glycosylation (366 aa)
       
 
  0.603
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Hydrolysis of urea to ammonia and CO(2) (1835 aa)
   
   
  0.540
IZH4
Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels (312 aa)
     
   
0.530
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed-1978720, PubMed-7947684). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed-1978720). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed-1978720, Pu [...] (510 aa)
     
 
  0.505
YJL132W
Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene (750 aa)
           
  0.485
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids; Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole (2233 aa)
   
   
  0.482
PTM1
Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p (523 aa)
           
  0.446
NRG2
Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p; Transcriptional repressor (220 aa)
       
 
  0.430
VEL1
Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants (206 aa)
       
 
  0.429
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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