| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AXL2 | CSI2 | YIL140W | YOL007C | Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate. | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | 0.547 |
| CSI1 | CSI2 | YMR025W | YOL007C | Cop9 signalosome-interactor 1; Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome. | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | 0.699 |
| CSI2 | AXL2 | YOL007C | YIL140W | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate. | 0.547 |
| CSI2 | CSI1 | YOL007C | YMR025W | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Cop9 signalosome-interactor 1; Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome. | 0.699 |
| CSI2 | KRE9 | YOL007C | YJL174W | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects. | 0.571 |
| CSI2 | MCD1 | YOL007C | YDL003W | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Sister chromatid cohesion protein 1; Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase. | 0.436 |
| CSI2 | PPS1 | YOL007C | YBR276C | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.606 |
| CSI2 | SDP1 | YOL007C | YIL113W | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.439 |
| CSI2 | TOS4 | YOL007C | YLR183C | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Protein TOS4; Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress. | 0.469 |
| CSI2 | TOS6 | YOL007C | YNL300W | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Protein TOS6; Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid. | 0.612 |
| CSI2 | YOX1 | YOL007C | YML027W | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Homeobox protein YOX1; Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication. | 0.481 |
| CSI2 | YPS5 | YOL007C | YGL259W | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | Yapsin-5; Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p; mCherry fusion protein localizes to the vacuole; Belongs to the peptidase A1 family. | 0.429 |
| KRE9 | CSI2 | YJL174W | YOL007C | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects. | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | 0.571 |
| KRE9 | PPS1 | YJL174W | YBR276C | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects. | Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.501 |
| MCD1 | CSI2 | YDL003W | YOL007C | Sister chromatid cohesion protein 1; Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase. | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | 0.436 |
| MCD1 | TOS4 | YDL003W | YLR183C | Sister chromatid cohesion protein 1; Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase. | Protein TOS4; Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress. | 0.462 |
| MCD1 | YOX1 | YDL003W | YML027W | Sister chromatid cohesion protein 1; Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase. | Homeobox protein YOX1; Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication. | 0.658 |
| PPS1 | CSI2 | YBR276C | YOL007C | Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene. | 0.606 |
| PPS1 | KRE9 | YBR276C | YJL174W | Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects. | 0.501 |
| PPS1 | SDP1 | YBR276C | YIL113W | Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.802 |