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NGL1 protein (Saccharomyces cerevisiae) - STRING interaction network
"NGL1" - Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p in Saccharomyces cerevisiae
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
NGL1Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies (363 aa)    
Predicted Functional Partners:
POP2
RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3’ to 5’ mRNA deadenylation; Acts as probably catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. In vitro, POP2 has 3’- exoribonuclease activity with a preference for poly(A) RNAs, but also degrades poly(U) and poly(C) RNAs. Is part of a glucose- sensing system involved in growth control in response to glucose availability (433 aa)
     
 
  0.945
CDC39
Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC- type TATA element-dependent transcription. Could directly or indirectly inhibit co [...] (2108 aa)
     
 
  0.936
NGL3
3’-5’ exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p (505 aa)
     
   
  0.784
YOL037C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W (117 aa)
           
  0.748
NGL2
Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3’-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p; Involved in pre-rRNA processing. Required for the final stage of 3’-end maturation of 5.8S rRNA at site E (515 aa)
     
   
  0.743
CDC36
Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent tran [...] (191 aa)
     
 
  0.609
RNH70
3’-5’ exoribonuclease; required for maturation of 3’ ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts; 3’ exoribonuclease required for 5S rRNA maturation and for the proper maturation of the 5’ cistron of the tRNA-Arg3 dicistronic gene. Involved with REX2 in the maturation of the 5.8S rRNA, and with REX2 and REX3, in the 3’ processing of the U5L snRNA (553 aa)
     
   
  0.593
HSH155
U2-snRNP associated splicing factor; forms extensive associations with the branch site-3’ splice site-3’ exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155; Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly (971 aa)
     
   
  0.577
SGN1
Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation; mRNA-binding protein that may play a role in modulating the expression of cytoplasmic mRNA (250 aa)
       
 
  0.555
APN2
Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII; DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3’-blocking groups present at single strand breaks of damaged DNA (520 aa)
     
 
  0.551
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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