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PAP2 protein (Saccharomyces cerevisiae) - STRING interaction network
"PAP2" - Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex in Saccharomyces cerevisiae
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PAP2Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p; Catalytic subunit of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts gene [...] (584 aa)    
Predicted Functional Partners:
AIR2
Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p; Component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III [...] (344 aa)
     
  0.999
MTR4
ATP-dependent 3’-5’ RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes; has a KOW domain that shows RNA binding activity; ATP-dependent RNA helicase required for the 3’-end formation of 5.8S RNA. Cofactor for the exosome complex that unwinds secondary structure in pre-rRNA. Required for nucleocytoplasmic transport of mRNA. May serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export. Component of the TRAMP complex which has a pol [...] (1073 aa)
     
  0.999
AIR1
Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p; Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post- transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polyme [...] (360 aa)
     
  0.995
PAP1
Poly(A) polymerase, one of three factors required for mRNA 3’-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping; Polymerase component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3’-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB (568 aa)
     
 
  0.981
RRP6
Nuclear exosome exonuclease component; has 3’-5’ exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays red /.../ranscription elongation in the G-less-based run-on (GLRO) assay; Nuclear-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable [...] (733 aa)
     
 
  0.979
NRD1
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex mediates termination of snoRNAs and cryptic unstable transcripts (CUTs); interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially a /.../phorylated Ser5; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; required for 3’ end maturation of nonpolyadenylated RNAs; Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance (575 aa)
     
 
  0.976
NAB3
Single stranded RNA binding protein; subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing. Binds to poly(A)+ RNA. Appears to act in the maintenance of CLN3 mRNA levels (802 aa)
       
 
  0.967
TRF5
Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p; Catalytic subunit of the TRAMP5 complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts gen [...] (642 aa)
     
0.966
DIS3
Exosome core complex catalytic subunit; possesses both endonuclease and 3’-5’ exonuclease activity; involved in 3’-5’ RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; Catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and [...] (1001 aa)
     
 
  0.897
RAT1
Nuclear 5’ to 3’ single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination; Possesses 5’->3’ exoribonuclease activity. Required for the processing of nuclear mRNA, rRNA and small nucleolar RNA (snoRNA) precursors. May promote termination of transcription by RNA polymerase II via the recruitment of 3’-end processing factors to the poly(A) site and by the degradation of nascent RNA downstream of the poly(A) site (1006 aa)
     
 
  0.895
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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