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MCH4 protein (Saccharomyces cerevisiae) - STRING interaction network
"MCH4" - Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane in Saccharomyces cerevisiae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MCH4Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane (501 aa)    
Predicted Functional Partners:
RIB5
Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway; Catalyzes the dismutation of two molecules of 6,7- dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil (238 aa)
     
 
  0.680
YOL118C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (102 aa)
           
  0.636
TMT1
Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The [...] (299 aa)
     
        0.625
ARG4
Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway (463 aa)
     
        0.592
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway (523 aa)
           
  0.579
YGL114W
Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters (725 aa)
     
        0.511
NIT1
Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene (199 aa)
     
        0.492
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity; Exhibits dehydratase activity specific for L-threo-3- hydroxyaspartate (326 aa)
     
   
  0.479
MCH1
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane (486 aa)
     
   
  0.474
FMN1
Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme (218 aa)
           
  0.469
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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