node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTF13 | PET127 | YMR094W | YOR017W | Subunit of the CBF3 complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis. | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | 0.604 |
DSS1 | PET127 | YMR287C | YOR017W | 3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs. | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | 0.724 |
DSS1 | PUF3 | YMR287C | YLL013C | 3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs. | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | 0.754 |
DSS1 | SUV3 | YMR287C | YPL029W | 3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs. | ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant. | 0.999 |
DSS1 | TRZ1 | YMR287C | YKR079C | 3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs. | Ribonuclease Z; tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2. | 0.597 |
OLI1 | PET127 | Q0130 | YOR017W | F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2. | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | 0.586 |
OLI1 | RPO41 | Q0130 | YFL036W | F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2. | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Rpo41p also synthesizes RNA primers for mitochondrial DNA replication. | 0.594 |
OLI1 | SUV3 | Q0130 | YPL029W | F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2. | ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant. | 0.430 |
OLI1 | TRZ1 | Q0130 | YKR079C | F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2. | Ribonuclease Z; tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2. | 0.483 |
PET122 | PET127 | YER153C | YOR017W | Protein PET122, mitochondrial; Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane. | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | 0.627 |
PET127 | CTF13 | YOR017W | YMR094W | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | Subunit of the CBF3 complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis. | 0.604 |
PET127 | DSS1 | YOR017W | YMR287C | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | 3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs. | 0.724 |
PET127 | OLI1 | YOR017W | Q0130 | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2. | 0.586 |
PET127 | PET122 | YOR017W | YER153C | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | Protein PET122, mitochondrial; Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane. | 0.627 |
PET127 | PUF3 | YOR017W | YLL013C | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | 0.730 |
PET127 | RPO41 | YOR017W | YFL036W | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Rpo41p also synthesizes RNA primers for mitochondrial DNA replication. | 0.762 |
PET127 | SUV3 | YOR017W | YPL029W | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant. | 0.904 |
PET127 | TRZ1 | YOR017W | YKR079C | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | Ribonuclease Z; tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2. | 0.663 |
PET127 | YJL070C | YOR017W | YJL070C | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | Inactive deaminase YJL070C; Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication. | 0.635 |
PET127 | YOR015W | YOR017W | YOR015W | Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane. | Uncharacterized protein YOR015W; Putative protein of unknown function; conserved among S. cerevisiae strains; YOR015W is not an essential gene. | 0.702 |