STRINGSTRING
IRC23 protein (Saccharomyces cerevisiae) - STRING interaction network
"IRC23" - Putative protein of unknown function in Saccharomyces cerevisiae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
IRC23Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; Is probably involved in a pathway contributing to genomic integrity (157 aa)    
Predicted Functional Partners:
CNL1
Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting (122 aa)
       
      0.738
ERP4
Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; Involved in vesicular protein trafficking (207 aa)
       
      0.673
HRD1
Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, [...] (551 aa)
       
      0.673
YOL079W
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (132 aa)
           
  0.543
YHR078W
High osmolarity-regulated gene of unknown function (552 aa)
           
  0.543
MIL1
Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk (1073 aa)
           
  0.507
YOR365C
Putative protein of unknown function; YOR365C is not an essential protein (703 aa)
           
  0.485
YLR152C
Putative protein of unknown function; YLR152C is not an essential gene (576 aa)
           
  0.480
YAR028W
Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS (234 aa)
           
  0.452
ENV10
Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene; Involved in vacuolar processing and morphology (181 aa)
           
  0.448
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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