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PIN2 protein (Saccharomyces cerevisiae) - STRING interaction network
"PIN2" - Protein that induces appearance of [PIN+] prion when overproduced in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PIN2Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated; Not known. Seems to be able to provoque the non- Mendelian trait [PIN(+)] which is required for the de novo appearance of the [PSI(+)] prion (282 aa)    
Predicted Functional Partners:
DRS2
Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly (1355 aa)
       
 
  0.880
SMI1
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity; Protein involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of cell wall glucan and chitin synthesis (505 aa)
       
      0.806
RGD2
GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; Acts in signal transduction. Activates CDC42 and RHO5 (714 aa)
       
      0.806
RNQ1
[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate; Transferable epigenetic modifier which forms a prion responsible for the non-Mendelian trait [PIN+]. The native function of the soluble protein is unknown (405 aa)
           
  0.697
PIN3
Protein that induces appearance of [PIN+] prion when overproduced; Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress (215 aa)
           
  0.680
SUP35
Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype; Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides. Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs. Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening (685 aa)
       
 
  0.662
URE2
Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion; Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of gen [...] (354 aa)
       
 
  0.572
PIN4
Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage; Involved in normal G2/M phase transition of the mitotic cell cycle. In association with RAD53, also involved in checkpoint control in response to DNA damage (668 aa)
           
  0.507
YBL081W
Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport (368 aa)
           
  0.487
NEW1
ATP binding cassette protein; cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction; May be involved in the mRNA export process (By similarity). Forms the [NU+] prion and induces [PSI+] prion formation (1196 aa)
           
  0.481
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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