node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADK1 | ADK2 | YDR226W | YER170W | Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant. | GTP:AMP phosphotransferase, mitochondrial; Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background. | 0.921 |
ADK1 | THI80 | YDR226W | YOR143C | Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant. | Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate). | 0.910 |
ADK2 | ADK1 | YER170W | YDR226W | GTP:AMP phosphotransferase, mitochondrial; Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background. | Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant. | 0.921 |
ADK2 | THI80 | YER170W | YOR143C | GTP:AMP phosphotransferase, mitochondrial; Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background. | Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate). | 0.908 |
BCY1 | THI80 | YIL033C | YOR143C | Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation. | Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate). | 0.993 |
DIA3 | PHO11 | YDL024C | YAR071W | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication. | 0.902 |
DIA3 | PHO12 | YDL024C | YHR215W | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication. | 0.902 |
DIA3 | PHO3 | YDL024C | YBR092C | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin. | 0.903 |
DIA3 | PHO5 | YDL024C | YBR093C | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; Belongs to the histidine acid phosphatase family. | 0.901 |
DIA3 | THI20 | YDL024C | YOL055C | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20; Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p; In the C-terminal section; belongs to the thiaminase-2 family. | 0.903 |
DIA3 | THI21 | YDL024C | YPL258C | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21; Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p; In the C-terminal section; belongs to the thiaminase-2 family. | 0.943 |
DIA3 | THI80 | YDL024C | YOR143C | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate). | 0.907 |
PHO11 | DIA3 | YAR071W | YDL024C | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication. | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | 0.902 |
PHO11 | PHO12 | YAR071W | YHR215W | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication. | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication. | 0.978 |
PHO11 | PHO3 | YAR071W | YBR092C | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication. | Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin. | 0.922 |
PHO11 | PHO5 | YAR071W | YBR093C | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication. | Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; Belongs to the histidine acid phosphatase family. | 0.984 |
PHO11 | THI20 | YAR071W | YOL055C | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20; Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p; In the C-terminal section; belongs to the thiaminase-2 family. | 0.900 |
PHO11 | THI21 | YAR071W | YPL258C | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21; Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p; In the C-terminal section; belongs to the thiaminase-2 family. | 0.900 |
PHO11 | THI80 | YAR071W | YOR143C | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication. | Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate). | 0.919 |
PHO12 | DIA3 | YHR215W | YDL024C | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication. | Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth. | 0.902 |