node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BFR1 | FYV12 | YOR198C | YOR183W | Nuclear segregation protein BFR1; Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.602 |
BFR1 | MGM1 | YOR198C | YOR211C | Nuclear segregation protein BFR1; Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity. | Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy. | 0.426 |
BFR1 | NPT1 | YOR198C | YOR209C | Nuclear segregation protein BFR1; Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity. | Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus. | 0.423 |
FYV12 | BFR1 | YOR183W | YOR198C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Nuclear segregation protein BFR1; Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity. | 0.602 |
FYV12 | GAC1 | YOR183W | YOR178C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog, PIG1, that arose from the whole genome duplication. | 0.514 |
FYV12 | MGM1 | YOR183W | YOR211C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy. | 0.515 |
FYV12 | MIL1 | YOR183W | YFL034W | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | 0.539 |
FYV12 | NPT1 | YOR183W | YOR209C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus. | 0.638 |
FYV12 | RPS30B | YOR183W | YOR182C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30B has a paralog, RPS30A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress. | 0.608 |
FYV12 | SER1 | YOR183W | YOR184W | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.537 |
FYV12 | SLK19 | YOR183W | YOR195W | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate. | 0.510 |
FYV12 | THI72 | YOR183W | YOR192C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p. | 0.639 |
FYV12 | ULS1 | YOR183W | YOR191W | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | ATP-dependent helicase ULS1; Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress. | 0.535 |
GAC1 | FYV12 | YOR178C | YOR183W | Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog, PIG1, that arose from the whole genome duplication. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.514 |
MGM1 | BFR1 | YOR211C | YOR198C | Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy. | Nuclear segregation protein BFR1; Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity. | 0.426 |
MGM1 | FYV12 | YOR211C | YOR183W | Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.515 |
MIL1 | FYV12 | YFL034W | YOR183W | Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.539 |
NPT1 | BFR1 | YOR209C | YOR198C | Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus. | Nuclear segregation protein BFR1; Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity. | 0.423 |
NPT1 | FYV12 | YOR209C | YOR183W | Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.638 |
NPT1 | SER1 | YOR209C | YOR184W | Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus. | 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.763 |