STRINGSTRING
HER1 protein (Saccharomyces cerevisiae) - STRING interaction network
"HER1" - Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p in Saccharomyces cerevisiae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
HER1Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; Required for HMG2-induced endoplasmic reticulum- remodeling (1246 aa)    
Predicted Functional Partners:
BNI4
Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p (892 aa)
       
 
  0.709
YDL176W
Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene (708 aa)
           
  0.544
NOP2
Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing (618 aa)
       
 
  0.521
GLC7
Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg- glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; Involved in control of glycogen metabolism, meiosis, translation, chromosome segregation, cell polarity and G2/M cell cycle progression. PP1 may act in opposition to the IPL1 protein kinase in regulating chromosome segregation by dephosphorylating H3S10ph. The BUD14-GLC7 complex is necessary to regulate microtubule dynamics at the cortex and may fun [...] (312 aa)
       
 
  0.514
YOR342C
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus (319 aa)
           
  0.510
YDR514C
Protein of unknown function that localizes to mitochondria; overexpression of YDR514C affects endocytic protein trafficking (483 aa)
           
  0.502
FUN14
Mitochondrial protein of unknown function (198 aa)
           
  0.440
RTK1
Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; Probable serine/threonine-protein kinase that may be involved in ribosome biogenesis (620 aa)
     
      0.431
SEA4
Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites; Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis (1038 aa)
           
  0.430
YDL241W
Putative protein of unknown function; YDL241W is not an essential gene (123 aa)
           
  0.418
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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