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WTM1 protein (Saccharomyces cerevisiae) - STRING interaction network
"WTM1" - Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes in Saccharomyces cerevisiae
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Predicted Interactions
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WTM1Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats; Transcriptional modulator with roles in meiotic regulation and silencing. Acts either as an adapter to facilitate nuclear import by KAP122 of the RNR2-RNR4 herodimer, also called beta-beta’ subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR); or as an anchor to retain RNR2- RNR4 in the nucleus (437 aa)    
Predicted Functional Partners:
RNR2
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center (399 aa)
     
 
  0.954
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR4 is required for proper folding of RNR2 and assembly with the large subunits (345 aa)
     
 
  0.901
DIF1
Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein; Mediates the nuclear localization of RNR2 and RNR4, 2 subunits of the ribonucleotide reductase (133 aa)
       
 
  0.819
SML1
Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; Strong inhibitor of ribonucleotide reductase (RNR1) and is involved in regulating dNTP production (104 aa)
       
 
  0.769
MEC1
Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited in complex with protein LCD1 by the single-strand-binding protein comp [...] (2368 aa)
       
 
  0.740
PTC2
Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; Responsible, together with PTC3, for the dephosphorylation of the cyclin-dependent protein kinase CDC28 (464 aa)
       
 
  0.735
WTM2
Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; Transcriptional modulator with roles in meiotic regulation and silencing (467 aa)
       
 
0.707
YHB1
Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (399 aa)
       
      0.692
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3’-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; Binds to specific AU-rich elements (ARE) in the 3’- untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Recruits the DHH1 helicase to the SDH4 mRNA and promotes SDH4 mRNA decay. Also destabilizes target mRNA by modulating 3’-end processing, creating extended trans [...] (285 aa)
       
 
  0.686
KAP122
Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance; Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2- RNR4 heterodimer, also called beta-beta’ subunit, which corresponds to the small subunit of t [...] (1081 aa)
       
 
  0.682
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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