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GPN2 protein (Saccharomyces cerevisiae) - STRING interaction network
"GPN2" - Protein of unknown function required for establishment of sister chromatid cohesion in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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GPN2Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import (PubMed-23267056). Required for establishment of sister chromatid cohesion (PubMed-18439903) (347 aa)    
Predicted Functional Partners:
NPA3
Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kina /.../plex; human homolog XAB1 interacts with human RNA polymerase II; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed-20855544, PubMed-21844196). May act at an RNAP assembly step prior to nuclear import (PubMed-23267056). Promotes sister chromatid separation during anaphase (PubMed-21532343) (385 aa)
   
 
0.968
RPB2
RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerases II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. During a transcr [...] (1224 aa)
       
 
  0.887
RPB10
RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is [...] (70 aa)
     
 
  0.867
RPB11
RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft. Seems to be involved transcript term [...] (120 aa)
     
 
  0.827
RBA50
Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (439 aa)
     
      0.815
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; Weakly expressed functional homolog of translation elongation factor 3A (YEF3), not required for survival. Can complement loss of YEF3 when expressed from the YEF3 or ADH1 promoters. Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis. Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which [...] (1044 aa)
     
      0.805
IWR1
RNA polymerase II transport factor, conserved from yeast to humans; involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor; interacts with most of the RNAP II subunits; nu /.../ytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; Directs RNA polymerase II nuclear import. Binds RNA polymerase II in the active center cleft between the two largest subunits in the cytoplasm. Then uses an N-terminal bipartite nuclear localization signal that may be recognized by karyopherin alpha to d [...] (353 aa)
     
 
  0.778
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore (572 aa)
       
 
  0.697
SBA1
Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity; Acts as a co-chaperone (216 aa)
       
      0.674
RET1
Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the co [...] (1149 aa)
     
 
  0.646
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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