node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALG1 | BET2 | YBR110W | YPR176C | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant. | Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant. | 0.472 |
ALG1 | YPK9 | YBR110W | YOR291W | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.573 |
APC5 | BET2 | YOR249C | YPR176C | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress; Belongs to the APC5 family. | Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant. | 0.414 |
APC5 | YPK9 | YOR249C | YOR291W | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress; Belongs to the APC5 family. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.658 |
BET2 | ALG1 | YPR176C | YBR110W | Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant. | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant. | 0.472 |
BET2 | APC5 | YPR176C | YOR249C | Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant. | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress; Belongs to the APC5 family. | 0.414 |
BET2 | YPK9 | YPR176C | YOR291W | Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.607 |
POL3 | YPK9 | YDL102W | YOR291W | Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER). | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.552 |
PRE1 | YPK9 | YER012W | YOR291W | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle; Belongs to the peptidase T1B family. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.726 |
SMF2 | YPK9 | YHR050W | YOR291W | Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; Belongs to the NRAMP family. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.611 |
SWF1 | YPK9 | YDR126W | YOR291W | Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.577 |
TDA4 | YPK9 | YJR116W | YOR291W | Topoisomerase I damage affected protein 4; Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; Belongs to the TMEM56 family. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.630 |
TDA4 | YPR114W | YJR116W | YPR114W | Topoisomerase I damage affected protein 4; Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; Belongs to the TMEM56 family. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.422 |
VPS13 | YPK9 | YLL040C | YOR291W | Vacuolar protein sorting-associated protein 13; Protein involved in prospore membrane morphogenesis; peripheral membrane protein that localizes to the prospore membrane and at numerous membrane contact sites; involved in sporulation, vacuolar protein sorting, prospore membrane formation during sporulation, and protein-Golgi retention; required for mitochondrial integrity; contains a PH-like domain; homologous to human CHAC and COH1 which are involved in Chorea-acanthocytosis and Cohen syndrome, respectively. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.578 |
YPK9 | ALG1 | YOR291W | YBR110W | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant. | 0.573 |
YPK9 | APC5 | YOR291W | YOR249C | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress; Belongs to the APC5 family. | 0.658 |
YPK9 | BET2 | YOR291W | YPR176C | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant. | 0.607 |
YPK9 | POL3 | YOR291W | YDL102W | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER). | 0.552 |
YPK9 | PRE1 | YOR291W | YER012W | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle; Belongs to the peptidase T1B family. | 0.726 |
YPK9 | SMF2 | YOR291W | YHR050W | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; Belongs to the NRAMP family. | 0.611 |