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AMF1 protein (Saccharomyces cerevisiae) - STRING interaction network
"AMF1" - Putative paralog of ATR1, but not required for boron tolerance in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AMF1Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug-H+ antiporters; YOR378W is not an essential gene; Probable ATP-dependent export permease involved in drug resistance through pumping them out of the cell (515 aa)    
Predicted Functional Partners:
VBA2
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine (474 aa)
   
     
  0.737
VBA5
Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny; Transporter required for vacuolar uptake of basic amino acids (582 aa)
   
     
  0.726
VBA3
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of histidine and lysine (458 aa)
   
     
  0.718
SGE1
Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations; Drug export permease. Multi-copy suppressor of loss-of- function mutation of GAL11. Involved specifically in transcription of GAL4-dependent genes. Can link GAL4 with the basal transcription machinery if GAL11 is missing. Confers resistance to 10-N-nonyl acridine orange (NAO) and in general to cationic dyes (543 aa)
   
     
  0.697
GEX2
Proton-glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway; Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway (615 aa)
           
  0.678
AZR1
Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole; Transporter protein required for adaptation to high stress imposed by low-chain organic acids, in particular by acetic acid, and for resistance to azoles, especially to ketoconazole and fluconazole (613 aa)
   
     
  0.643
VBA4
Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene; Transporter required for vacuolar uptake of basic amino acids (768 aa)
           
  0.640
GEX1
Proton-glutathione antiporter localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway (615 aa)
           
  0.580
HOL1
Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake; Seems to be involved in the uptake of several cations and of histidinol (586 aa)
           
  0.504
QDR3
Multidrug transporter of the major facilitator superfamily, has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin; Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro- 2-butynyl [3-chlorophenyl] carbamate) (689 aa)
           
  0.481
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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