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FRE3 protein (Saccharomyces cerevisiae) - STRING interaction network
"FRE3" - Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters in Saccharomyces cerevisiae
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Predicted Interactions
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FRE3Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane (711 aa)    
Predicted Functional Partners:
FTR1
High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; Permease for high affinity iron uptake (404 aa)
     
   
  0.830
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p; Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates (By similarity). Involved in iron homeostasis (686 aa)
           
  0.825
FET3
Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; Iron transport multicopper ferroxidase required for Fe(2+) ion high affinity uptake. Required to oxidize Fe(2+) and release it from the transporter. Essential component of copper- dependent iron transport (636 aa)
     
   
  0.818
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; Involved in the transport of siderophore ferrichrome and so has a role in iron homeostasis (627 aa)
     
   
  0.757
FET5
Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport; Iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport (622 aa)
     
   
  0.752
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C; Involved in the transport of siderophore triacestylfusarinine C and so has a role in iron homeostasis (620 aa)
     
   
  0.752
SMF3
Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; Has a role in controlling the cellular iron ion levels. Mobilizes vacuolar stores of iron in conditions of low iron levels (473 aa)
     
   
  0.737
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall; Involved in the uptake of non-siderophore and siderohpore sources of iron. Has a role in the retention of iron in the cell wall and periplasmic space (153 aa)
     
   
  0.730
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall; Involved in the uptake of non-siderophore and siderohpore sources of iron. Has a role in the retention of iron in the cell wall and periplasmic space (204 aa)
     
   
  0.717
SIT1
Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p; Involved in the transport of siderophore ferrioxamine B and so has a role in iron homeostasis (628 aa)
     
   
  0.699
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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