node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BNA7 | DAL7 | YDR428C | YIR031C | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | 0.800 |
BNA7 | FDH1 | YDR428C | YOR388C | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. | 0.900 |
BNA7 | FUM1 | YDR428C | YPL262W | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | Fumarate hydratase, mitochondrial; Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.800 |
BNA7 | MAE1 | YDR428C | YKL029C | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids. | 0.803 |
BNA7 | MDH1 | YDR428C | YKL085W | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; Belongs to the LDH/MDH superfamily. MDH type 1 family. | 0.800 |
BNA7 | MDH2 | YDR428C | YOL126C | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1. | 0.800 |
BNA7 | MDH3 | YDR428C | YDL078C | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle. | 0.800 |
BNA7 | MLS1 | YDR428C | YNL117W | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA. | 0.800 |
BNA7 | PYC2 | YDR428C | YBR218C | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication. | 0.800 |
DAL7 | BNA7 | YIR031C | YDR428C | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | 0.800 |
DAL7 | FDH1 | YIR031C | YOR388C | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. | 0.860 |
DAL7 | FUM1 | YIR031C | YPL262W | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | Fumarate hydratase, mitochondrial; Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.972 |
DAL7 | MAE1 | YIR031C | YKL029C | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids. | 0.980 |
DAL7 | MDH1 | YIR031C | YKL085W | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; Belongs to the LDH/MDH superfamily. MDH type 1 family. | 0.966 |
DAL7 | MDH2 | YIR031C | YOL126C | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1. | 0.979 |
DAL7 | MDH3 | YIR031C | YDL078C | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle. | 0.974 |
DAL7 | MLS1 | YIR031C | YNL117W | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA. | 0.938 |
DAL7 | PYC2 | YIR031C | YBR218C | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication. | 0.937 |
FDH1 | BNA7 | YOR388C | YDR428C | NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. | Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine. | 0.900 |
FDH1 | DAL7 | YOR388C | YIR031C | NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. | Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation. | 0.860 |