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YRF1-8 protein (Saccharomyces cerevisiae) - STRING interaction network
"YRF1-8" - One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1) in Saccharomyces cerevisiae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
YRF1-8One of several telomeric Y’ element-encoded DNA helicases, known as Y’-Help1 (Y’-HELicase Protein 1); Catalyzes DNA unwinding and is involved in telomerase- independent telomere maintenance (1796 aa)    
Predicted Functional Partners:
PRP22
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; Acts late in the splicing of pre-mRNA. Mediates the release of the spliced mRNA from spliceosomes (1145 aa)
   
 
  0.930
YLR466C-A
Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching (160 aa)
           
  0.903
DHR2
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis; Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis (735 aa)
     
 
  0.874
YDR545C-A
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-1/YDR545W (159 aa)
           
  0.830
YOR394C-A
Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching (55 aa)
           
  0.829
YDR544C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (142 aa)
           
  0.824
YDR543C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (99 aa)
           
  0.824
YER010C
Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (234 aa)
       
 
  0.766
CWC22
Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein; May be involved in pre-mRNA splicing (577 aa)
     
 
  0.703
TIF4632
Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p; Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus. Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5’- and 3’- ends of the mRNA in proximity. The formation of this circular mRNP structure appears to be critical [...] (914 aa)
     
  0.699
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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