STRINGSTRING
SMA1 protein (Saccharomyces cerevisiae) - STRING interaction network
"SMA1" - Protein of unknown function involved in the assembly of the prospore membrane during sporulation in Saccharomyces cerevisiae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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SMA1Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p; Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane (245 aa)    
Predicted Functional Partners:
MPC54
Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate; Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation (464 aa)
           
  0.637
SPO14
Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participat /.../transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events [...] (1683 aa)
       
 
  0.601
SPO74
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. Probable component of a core structural unit of the scaffold that initiates synthesis of the prospore membrane (413 aa)
           
  0.542
CDC10
Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds f /.../ruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus contributes septin interaction with phosphatidylinositol-4,5-bisphosphate; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form [...] (322 aa)
       
 
  0.522
MSO1
Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; Involved in secretion. Component of the secretory vesicle docking complex (210 aa)
           
  0.519
ADY3
Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; Involved in the pathway that organizes the prospore membrane (PSM) during sporulation. Mediates the assembly of the DON1 ring structure at the leading edge of PSM during meiosis II. May constitute a physical link between SSP1-containing PSM precursors and the spindle pole body (SPB) and may facilitate the recruitment of other factors that are required t [...] (790 aa)
           
  0.470
CDC3
Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud nec /.../as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, whi [...] (520 aa)
       
 
  0.457
ADY4
Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May be required to stabilize the outer plaque of the spindle pole body (SPB) (493 aa)
           
  0.447
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog; Required to maintain the prospore membrane to the nucleus during sporulation in order to capture the daughter nuclei and form the spores. Mediates the fusion of exocytic vesicles with the plasma membrane during sporulation through its interactions with the t-SNARE SSO1 and v-SNARE SNC2 (397 aa)
     
   
  0.445
DON1
Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; Involved in the pathway that organizes the prospore membrane (PSM) during sporulation (365 aa)
           
  0.440
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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