node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DOS2 | LCL1 | YDR068W | YPL056C | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | 0.511 |
DOS2 | YOR292C | YDR068W | YOR292C | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. | Vacuolar membrane protein YOR292C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene; Belongs to the peroxisomal membrane protein PXMP2/4 family. | 0.692 |
LCL1 | DOS2 | YPL056C | YDR068W | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm. | 0.511 |
LCL1 | LCL2 | YPL056C | YLR104W | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Long chronological lifespan protein 2; Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole. | 0.537 |
LCL1 | LCL3 | YPL056C | YGL085W | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Probable endonuclease LCL3; Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS. | 0.510 |
LCL1 | MUM2 | YPL056C | YBR057C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex; Belongs to the fl(2)d family. | 0.517 |
LCL1 | RRG8 | YPL056C | YPR116W | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Protein of unknown function; required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; Belongs to the RRG8 family. | 0.600 |
LCL1 | YLR407W | YPL056C | YLR407W | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Uncharacterized protein YLR407W; Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus. | 0.635 |
LCL1 | YMR099C | YPL056C | YMR099C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS. | 0.636 |
LCL1 | YOL014W | YPL056C | YOL014W | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Putative protein of unknown function; mCherry fusion protein localizes to the cytosol and nucleus. | 0.539 |
LCL1 | YOR292C | YPL056C | YOR292C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Vacuolar membrane protein YOR292C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene; Belongs to the peroxisomal membrane protein PXMP2/4 family. | 0.609 |
LCL1 | YOR343C | YPL056C | YOR343C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Uncharacterized protein YOR343C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.649 |
LCL2 | LCL1 | YLR104W | YPL056C | Long chronological lifespan protein 2; Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole. | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | 0.537 |
LCL2 | LCL3 | YLR104W | YGL085W | Long chronological lifespan protein 2; Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole. | Probable endonuclease LCL3; Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS. | 0.698 |
LCL2 | MUM2 | YLR104W | YBR057C | Long chronological lifespan protein 2; Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole. | Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex; Belongs to the fl(2)d family. | 0.601 |
LCL3 | LCL1 | YGL085W | YPL056C | Probable endonuclease LCL3; Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS. | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | 0.510 |
LCL3 | LCL2 | YGL085W | YLR104W | Probable endonuclease LCL3; Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS. | Long chronological lifespan protein 2; Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole. | 0.698 |
MUM2 | LCL1 | YBR057C | YPL056C | Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex; Belongs to the fl(2)d family. | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | 0.517 |
MUM2 | LCL2 | YBR057C | YLR104W | Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex; Belongs to the fl(2)d family. | Long chronological lifespan protein 2; Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole. | 0.601 |
RRG8 | LCL1 | YPR116W | YPL056C | Protein of unknown function; required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; Belongs to the RRG8 family. | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | 0.600 |