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MFM1 protein (Saccharomyces cerevisiae) - STRING interaction network
"MFM1" - Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
co-expression
protein homology
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MFM1Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing (413 aa)    
Predicted Functional Partners:
MRP13
Mitochondrial ribosomal protein of the small subunit (339 aa)
       
      0.687
MME1
Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene (368 aa)
       
 
  0.683
YHR180W
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data (163 aa)
           
  0.637
ALR1
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; Plasma membrane magnesium transporter (859 aa)
           
  0.543
MDM38
Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome; Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation (PubMed-11907266, PubMed-15138253). With MBA1, plays a role in ribosomal translation and protein insertion into the inner membrane (PubMed-20427570) (573 aa)
       
 
  0.538
PTH1
One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2 (190 aa)
       
 
  0.519
THP3
Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes; Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation. May also be involved in pre-mRNA splicing (470 aa)
           
  0.513
YPR146C
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (109 aa)
           
  0.487
MRS2
Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix (PubMed-12628916, PubMed-17827224, PubMed-20653776, PubMed-23999289). Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations [...] (470 aa)
     
 
0.459
FAT3
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies (750 aa)
           
  0.440
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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