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MEI5 protein (Saccharomyces cerevisiae) - STRING interaction network
"MEI5" - Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p in Saccharomyces cerevisiae
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MEI5Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p; Involved in meiotic DNA-break repair. Required for the recruitment of DCM1 to meiosis recombination hot spots (222 aa)    
Predicted Functional Partners:
SAE3
Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p; Involved in meiotic DNA-break repair. Required for the recruitment of DCM1 to meiosis recombination hot spots (91 aa)
     
 
  0.881
DMC1
Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; Required for meiotic recombination, synaptonemal complex formation and cell cycle progression. Recruited to meiosis recombination hotspots by MEI5 and SAE3 (334 aa)
       
 
  0.790
RAD51
Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; Required both for recombination and for the repair of DNA damage caused by X-rays. Its function may be modulated by interaction with other repair proteins. RAD52 interacts directly with RAD51, via its C-terminus. Forms a nucleoprotein filament with DNA as an early intermediate in recombination (400 aa)
       
 
  0.593
HED1
Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase; Involved in regulation of meiotic recombination and repair of DNA damage. Inhibits RAD51-mediated recombination when the meiotic recombination machinery is impaired (162 aa)
           
  0.580
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates DMC1-dependent homologous strand assimilation required for the resolution of meiotic double-strand breaks (218 aa)
     
   
  0.437
MEK1
Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; Probable protein kinase required for meiotic recombination (497 aa)
     
   
  0.426
YPR027C
Putative protein of unknown function (277 aa)
     
   
  0.419
YOL024W
Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site (172 aa)
           
  0.418
YLR030W
Putative protein of unknown function (263 aa)
           
  0.418
YIL024C
Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p (189 aa)
           
  0.418
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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