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CDC60 protein (Saccharomyces cerevisiae) - STRING interaction network
"CDC60" - Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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CDC60Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA (1090 aa)    
Predicted Functional Partners:
ILS1
Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A (1072 aa)
   
 
  0.999
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs; Catalyzes the attachment of methionine to tRNA(Met) in a two-step reaction- methionine is first activated by ATP to form Met-AMP and then transferred to the acceptor end of tRNA(Met) (751 aa)
     
 
  0.999
GUS1
Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction- glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). In mitochondria, constitutes the nondiscriminating glutamyl-tRNA synthase that generates the mitochondrial mischarged glutamyl- tRNA(Gln) substrate for the tRNA-dependent amid [...] (708 aa)
   
 
  0.996
ISM1
Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth (1002 aa)
   
 
  0.994
ALA1
Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (958 aa)
   
 
  0.993
YHR020W
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene (688 aa)
   
 
  0.991
GLN4
Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions (809 aa)
   
 
  0.991
YDR341C
Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (607 aa)
   
 
  0.989
VAS1
Mitochondrial and cytoplasmic valyl-tRNA synthetase (1104 aa)
     
 
  0.987
TYS1
Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36. Also involved in nuclear tRNA [...] (394 aa)
   
   
  0.982
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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