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HAA1 protein (Saccharomyces cerevisiae) - STRING interaction network
"HAA1" - Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins in Saccharomyces cerevisiae
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Known Interactions
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Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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HAA1Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress; Regulates the transcription of a set of genes, many of which encode membrane proteins. Among the genes regulated are YGR138C and YRO2. Does not seem to be dependent on copper (694 aa)    
Predicted Functional Partners:
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily; Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermine, but not spermidine (614 aa)
           
  0.752
YRO2
Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p (344 aa)
           
  0.720
TPO3
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily; Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Recognizes spermine, but not spermidine (622 aa)
           
  0.717
DRS1
Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles; ATP-binding RNA helicase involved in ribosome assembly (752 aa)
       
      0.675
TDA6
Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; Involved in vacuolar protein sorting (467 aa)
           
  0.626
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity; Plasma membrane transporter which mediates resistance to water-soluble, monocarboxylic acids with chain lengths of from C1 to C7 by active extrusion of the preservative anions from the cytosol. Also involved in the export of aromatic and branched- chain organic acids produced in amino acid catabolism (1511 aa)
           
  0.625
TPO1
Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane; Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Catalyzes polyamine uptake at alkaline pH and excretion at acidic pH. Recognizes spermidine, spermine and putrescine, the polyamine analogs methylglyoxal bis(guanylhydrazone) (MGBG) and paraquat, the antimalarial drug quinidine, and cycloheximide. Confers res [...] (586 aa)
       
 
  0.601
WAR1
Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively; Transcription factor which binds to a weak acid response element (WARE) to mediate stress induction of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively (944 aa)
           
  0.579
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p; May be involved in cellular adaptations prior to stationary phase (354 aa)
           
  0.576
SOD1
Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (154 aa)
       
 
  0.526
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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