node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPA12 | RPA135 | YJR063W | YPR010C | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase I second largest subunit A135. | 0.999 |
RPA12 | RPA34 | YJR063W | YJL148W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p; Belongs to the eukaryotic RPA34 RNA polymerase subunit family. | 0.999 |
RPA12 | RPA43 | YJR063W | YOR340C | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase I subunit A43; Belongs to the eukaryotic RPA43 RNA polymerase subunit family. | 0.999 |
RPA12 | RPA49 | YJR063W | YNL248C | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p. | 0.999 |
RPA12 | RPB10 | YJR063W | YOR210W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III. | 0.999 |
RPA12 | RPB5 | YJR063W | YBR154C | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.999 |
RPA12 | RPB8 | YJR063W | YOR224C | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III. | 0.999 |
RPA12 | RPC10 | YJR063W | YHR143W-A | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | 0.999 |
RPA12 | RPC19 | YJR063W | YNL113W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | RNA polymerase subunit AC19; common to RNA polymerases I and III. | 0.999 |
RPA12 | RRN3 | YJR063W | YKL125W | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family. | 0.999 |
RPA135 | RPA12 | YPR010C | YJR063W | RNA polymerase I second largest subunit A135. | RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.999 |
RPA135 | RPA34 | YPR010C | YJL148W | RNA polymerase I second largest subunit A135. | RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p; Belongs to the eukaryotic RPA34 RNA polymerase subunit family. | 0.999 |
RPA135 | RPA43 | YPR010C | YOR340C | RNA polymerase I second largest subunit A135. | RNA polymerase I subunit A43; Belongs to the eukaryotic RPA43 RNA polymerase subunit family. | 0.999 |
RPA135 | RPA49 | YPR010C | YNL248C | RNA polymerase I second largest subunit A135. | RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p. | 0.999 |
RPA135 | RPB10 | YPR010C | YOR210W | RNA polymerase I second largest subunit A135. | RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III. | 0.999 |
RPA135 | RPB5 | YPR010C | YBR154C | RNA polymerase I second largest subunit A135. | RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. | 0.999 |
RPA135 | RPB8 | YPR010C | YOR224C | RNA polymerase I second largest subunit A135. | RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III. | 0.999 |
RPA135 | RPC10 | YPR010C | YHR143W-A | RNA polymerase I second largest subunit A135. | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | 0.999 |
RPA135 | RPC19 | YPR010C | YNL113W | RNA polymerase I second largest subunit A135. | RNA polymerase subunit AC19; common to RNA polymerases I and III. | 0.999 |
RPA135 | RRN3 | YPR010C | YKL125W | RNA polymerase I second largest subunit A135. | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family. | 0.999 |