node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APC1 | YJL175W | YNL172W | YJL175W | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; Belongs to the APC1 family. | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | 0.416 |
APC1 | YNL171C | YNL172W | YNL171C | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; Belongs to the APC1 family. | Putative uncharacterized protein YNL171C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.705 |
APC1 | YPR050C | YNL172W | YPR050C | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; Belongs to the APC1 family. | Putative uncharacterized membrane protein YPR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W. | 0.483 |
EIS1 | YJL175W | YMR031C | YJL175W | Eisosome protein 1; Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication. | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | 0.510 |
EIS1 | YMR031W-A | YMR031C | YMR031W-A | Eisosome protein 1; Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication. | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C. | 0.484 |
EIS1 | YNL171C | YMR031C | YNL171C | Eisosome protein 1; Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication. | Putative uncharacterized protein YNL171C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.482 |
EIS1 | YPR050C | YMR031C | YPR050C | Eisosome protein 1; Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication. | Putative uncharacterized membrane protein YPR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W. | 0.692 |
MAK3 | YPR050C | YPR051W | YPR050C | N-alpha-acetyltransferase 30; Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, Naa60, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, Naa35; Naa60, the human NatF gene, also complements the null allele; Belongs to the acetyltransferase family. MAK3 subfamily. | Putative uncharacterized membrane protein YPR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W. | 0.712 |
YDR455C | YJL175W | YDR455C | YJL175W | Putative uncharacterized protein YDR455C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W. | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | 0.611 |
YDR455C | YMR031W-A | YDR455C | YMR031W-A | Putative uncharacterized protein YDR455C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W. | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C. | 0.638 |
YDR455C | YNL171C | YDR455C | YNL171C | Putative uncharacterized protein YDR455C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W. | Putative uncharacterized protein YNL171C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.560 |
YDR455C | YPR050C | YDR455C | YPR050C | Putative uncharacterized protein YDR455C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W. | Putative uncharacterized membrane protein YPR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W. | 0.655 |
YJL175W | APC1 | YJL175W | YNL172W | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; Belongs to the APC1 family. | 0.416 |
YJL175W | EIS1 | YJL175W | YMR031C | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | Eisosome protein 1; Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication. | 0.510 |
YJL175W | YDR455C | YJL175W | YDR455C | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | Putative uncharacterized protein YDR455C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W. | 0.611 |
YJL175W | YMR031W-A | YJL175W | YMR031W-A | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C. | 0.709 |
YJL175W | YNL171C | YJL175W | YNL171C | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | Putative uncharacterized protein YNL171C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.697 |
YJL175W | YPR050C | YJL175W | YPR050C | Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor. | Putative uncharacterized membrane protein YPR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W. | 0.765 |
YMR031W-A | EIS1 | YMR031W-A | YMR031C | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C. | Eisosome protein 1; Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication. | 0.484 |
YMR031W-A | YDR455C | YMR031W-A | YDR455C | Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C. | Putative uncharacterized protein YDR455C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W. | 0.638 |