node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CST6 | NCE103 | YIL036W | YNL036W | ATF/CREB activator 2; Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication. | Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress. | 0.529 |
CST6 | YPR064W | YIL036W | YPR064W | ATF/CREB activator 2; Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication. | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | 0.600 |
GIP3 | NCE103 | YPL137C | YNL036W | GLC7-interacting protein 3; Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication. | Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress. | 0.478 |
GIP3 | YPR064W | YPL137C | YPR064W | GLC7-interacting protein 3; Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication. | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | 0.510 |
NCE103 | CST6 | YNL036W | YIL036W | Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress. | ATF/CREB activator 2; Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication. | 0.529 |
NCE103 | GIP3 | YNL036W | YPL137C | Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress. | GLC7-interacting protein 3; Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication. | 0.478 |
NCE103 | YPR064W | YNL036W | YPR064W | Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress. | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | 0.597 |
ROX1 | YPR064W | YPR065W | YPR064W | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance. | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | 0.410 |
SMX2 | STO1 | YFL017W-A | YMR125W | Small nuclear ribonucleoprotein G; Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G. | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | 0.984 |
SMX2 | YPR064W | YFL017W-A | YPR064W | Small nuclear ribonucleoprotein G; Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G. | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | 0.491 |
STO1 | SMX2 | YMR125W | YFL017W-A | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | Small nuclear ribonucleoprotein G; Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G. | 0.984 |
STO1 | YPR064W | YMR125W | YPR064W | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | 0.491 |
YPR064W | CST6 | YPR064W | YIL036W | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | ATF/CREB activator 2; Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication. | 0.600 |
YPR064W | GIP3 | YPR064W | YPL137C | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | GLC7-interacting protein 3; Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication. | 0.510 |
YPR064W | NCE103 | YPR064W | YNL036W | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress. | 0.597 |
YPR064W | ROX1 | YPR064W | YPR065W | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance. | 0.410 |
YPR064W | SMX2 | YPR064W | YFL017W-A | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | Small nuclear ribonucleoprotein G; Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G. | 0.491 |
YPR064W | STO1 | YPR064W | YMR125W | Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene. | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | 0.491 |