node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAD1 | FMN1 | YDL045C | YDR236C | FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1. | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation. | 0.998 |
FAD1 | LTP1 | YDL045C | YPR073C | FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1. | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | 0.951 |
FAD1 | PHO12 | YDL045C | YHR215W | FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1. | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication. | 0.900 |
FAD1 | PHO3 | YDL045C | YBR092C | FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1. | Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin. | 0.900 |
FAD1 | RIB5 | YDL045C | YBR256C | FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1. | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway. | 0.812 |
FMN1 | FAD1 | YDR236C | YDL045C | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation. | FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1. | 0.998 |
FMN1 | LTP1 | YDR236C | YPR073C | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation. | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | 0.907 |
FMN1 | PHO12 | YDR236C | YHR215W | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation. | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication. | 0.900 |
FMN1 | PHO3 | YDR236C | YBR092C | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation. | Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin. | 0.900 |
FMN1 | RIB5 | YDR236C | YBR256C | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation. | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway. | 0.997 |
LTP1 | FAD1 | YPR073C | YDL045C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1. | 0.951 |
LTP1 | FMN1 | YPR073C | YDR236C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation. | 0.907 |
LTP1 | PHO12 | YPR073C | YHR215W | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication. | 0.921 |
LTP1 | PHO3 | YPR073C | YBR092C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin. | 0.901 |
LTP1 | PHO8 | YPR073C | YDR481C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN. | 0.911 |
LTP1 | RIB5 | YPR073C | YBR256C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway. | 0.902 |
LTP1 | THI20 | YPR073C | YOL055C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20; Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p; In the C-terminal section; belongs to the thiaminase-2 family. | 0.905 |
LTP1 | THI21 | YPR073C | YPL258C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21; Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p; In the C-terminal section; belongs to the thiaminase-2 family. | 0.905 |
LTP1 | THI6 | YPR073C | YPL214C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | Thiamine biosynthetic bifunctional enzyme; Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern. | 0.905 |
LTP1 | THI80 | YPR073C | YOR143C | Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine. | Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate). | 0.902 |