node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASR1 | KEX2 | YPR093C | YNL238W | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway; Belongs to the peptidase S8 family. Furin subfamily. | 0.904 |
ASR1 | RPB11 | YPR093C | YOL005C | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | 0.815 |
ASR1 | RPB2 | YPR093C | YOR151C | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | 0.819 |
ASR1 | RPB3 | YPR093C | YIL021W | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | 0.839 |
ASR1 | RPB4 | YPR093C | YJL140W | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.837 |
ASR1 | RPB9 | YPR093C | YGL070C | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription. | 0.786 |
ASR1 | RPO21 | YPR093C | YDL140C | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. | 0.882 |
ASR1 | RPO26 | YPR093C | YPR187W | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. | 0.810 |
ASR1 | RPS31 | YPR093C | YLR167W | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog. | 0.795 |
ASR1 | UBC1 | YPR093C | YDR177W | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex (APC); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress key E2 partner with Ubc4p for the anaphase-promoting complex (APC). | 0.838 |
KEX2 | ASR1 | YNL238W | YPR093C | Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway; Belongs to the peptidase S8 family. Furin subfamily. | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | 0.904 |
RPB11 | ASR1 | YOL005C | YPR093C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | 0.815 |
RPB11 | RPB2 | YOL005C | YOR151C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | 0.999 |
RPB11 | RPB3 | YOL005C | YIL021W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit. | 0.999 |
RPB11 | RPB4 | YOL005C | YJL140W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation. | 0.999 |
RPB11 | RPB9 | YOL005C | YGL070C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription. | 0.999 |
RPB11 | RPO21 | YOL005C | YDL140C | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime. | 0.999 |
RPB11 | RPO26 | YOL005C | YPR187W | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. | 0.999 |
RPB2 | ASR1 | YOR151C | YPR093C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein. | 0.819 |
RPB2 | RPB11 | YOR151C | YOL005C | RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit. | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit. | 0.999 |