node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APQ12 | YPK9 | YIL040W | YOR291W | Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; Belongs to the APQ12 family. | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.507 |
APQ12 | YPR071W | YIL040W | YPR071W | Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; Belongs to the APQ12 family. | Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication. | 0.443 |
APQ12 | YPR114W | YIL040W | YPR114W | Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; Belongs to the APQ12 family. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.514 |
BBC1 | YPR114W | YJL020C | YPR114W | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.549 |
BBP1 | PUF3 | YPL255W | YLL013C | Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p; Belongs to the BBP1 family. | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | 0.540 |
BBP1 | YPR071W | YPL255W | YPR071W | Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p; Belongs to the BBP1 family. | Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication. | 0.446 |
BBP1 | YPR114W | YPL255W | YPR114W | Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p; Belongs to the BBP1 family. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.480 |
GUK1 | TUB2 | YDR454C | YFL037W | Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins. | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria. | 0.646 |
GUK1 | YPR114W | YDR454C | YPR114W | Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.481 |
PUF3 | BBP1 | YLL013C | YPL255W | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p; Belongs to the BBP1 family. | 0.540 |
PUF3 | YPR114W | YLL013C | YPR114W | mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.625 |
TUB2 | GUK1 | YFL037W | YDR454C | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria. | Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins. | 0.646 |
TUB2 | YPR114W | YFL037W | YPR114W | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.566 |
YDL121C | YPR071W | YDL121C | YPR071W | ER export of PMA1 protein 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein. | Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication. | 0.609 |
YDL121C | YPR114W | YDL121C | YPR114W | ER export of PMA1 protein 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.698 |
YPC1 | YPR114W | YBR183W | YPR114W | Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.482 |
YPK9 | APQ12 | YOR291W | YIL040W | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; Belongs to the APQ12 family. | 0.507 |
YPK9 | YPR114W | YOR291W | YPR114W | Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Uncharacterized TLC domain-containing protein YPR114W; Putative protein of unknown function. | 0.573 |
YPR071W | APQ12 | YPR071W | YIL040W | Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication. | Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; Belongs to the APQ12 family. | 0.443 |
YPR071W | BBP1 | YPR071W | YPL255W | Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication. | Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p; Belongs to the BBP1 family. | 0.446 |